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22 Additionally, K673-peptide-3# (K673-pe), a peptidic inhibitor, suppresses MRE11 K673 lactylation to block DSB repair-mediated HR hyperactivation and sensitize CRC cells to chemotherapy, resulting in a synergistic tumor-suppressive effect
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In pathological conditions, peripheral immune cells, such as T cells and neutrophils, may also infiltrate the brain and spinal cord, further intensifying the inflammation (246, 247)